Pyroglutamate-Modified Amyloid-β(3–42) Shows α-Helical Intermediates before Amyloid Formation

Pyroglutamate-modified amyloid-β (pEAβ) has been described as a relevant Aβ species in Alzheimer’s-disease-affected brains, with pEAβ (3–42) as a dominant isoform. Aβ (1–40) and Aβ (1–42) have been well characterized under various solution conditions, including aqueous solutions containing trifluoro...

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Vydáno v:Biophys J
Hlavní autoři: Dammers, Christina, Reiss, Kerstin, Gremer, Lothar, Lecher, Justin, Ziehm, Tamar, Stoldt, Matthias, Schwarten, Melanie, Willbold, Dieter
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2017
Témata:
Proteins
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5406372/
https://ncbi.nlm.nih.gov/pubmed/28445753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.03.007
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