IL-6 and PD-L1 antibody blockade combination therapy reduces tumor progression in murine models of pancreatic cancer

OBJECTIVE: Limited efficacy of immune checkpoint inhibitors in pancreatic ductal adenocarcinoma (PDAC) has prompted investigation into combination therapy. We hypothesized that IL-6 blockade would modulate immunologic features of PDAC and enhance the efficacy of anti-PD-L1 checkpoint inhibitor thera...

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Udgivet i:Gut
Main Authors: Mace, Thomas A., Shakya, Reena, Pitarresi, Jason R., Swanson, Benjamin, McQuinn, Christopher W., Loftus, Shannon, Nordquist, Emily, Cruz-Monserrate, Zobeida, Yu, Lianbo, Young, Gregory, Zhong, Xiaoling, Zimmers, Teresa A., Ostrowski, Michael C., Ludwig, Thomas, Bloomston, Mark, Bekaii-Saab, Tanios, Lesinski, Gregory B.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5406266/
https://ncbi.nlm.nih.gov/pubmed/27797936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2016-311585
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