Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9

Bacterial biofilms are associated with numerous human infections. The predominant protein expressed in enteric biofilms is the amyloid curli, which forms highly immunogenic complexes with DNA. Infection with curli-expressing bacteria or systemic exposure to purified curli-DNA complexes triggers auto...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Tursi, Sarah A., Lee, Ernest Y., Medeiros, Nicole J., Lee, Michael H., Nicastro, Lauren K., Buttaro, Bettina, Gallucci, Stefania, Wilson, Ronald Paul, Wong, Gerard C. L., Tükel, Çagla
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5406031/
https://ncbi.nlm.nih.gov/pubmed/28410407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006315
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