Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD

OBJECTIVE: To examine whether a polygenic risk score (PRS) derived from APOE4, CLU, and ABCA7 is associated with CSF biomarkers of Alzheimer disease (AD) pathology and whether higher cardiorespiratory fitness (CRF) modifies the association between the PRS and CSF biomarkers. METHODS: Ninety-five ind...

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Gepubliceerd in:Neurology
Hoofdauteurs: Schultz, Stephanie A., Boots, Elizabeth A., Darst, Burcu F., Zetterberg, Henrik, Blennow, Kaj, Edwards, Dorothy F., Koscik, Rebecca L., Carlsson, Cynthia M., Gallagher, Catherine L., Bendlin, Barbara B., Asthana, Sanjay, Sager, Mark A., Hogan, Kirk J., Hermann, Bruce P., Cook, Dane B., Johnson, Sterling C., Engelman, Corinne D., Okonkwo, Ozioma C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Lippincott Williams & Wilkins 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405766/
https://ncbi.nlm.nih.gov/pubmed/28341646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000003862
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