Stepwise assembly of functional C‐terminal REST/NRSF transcriptional repressor complexes as a drug target

In human cells, thousands of predominantly neuronal genes are regulated by the repressor element 1 (RE1)‐silencing transcription factor/neuron‐restrictive silencer factor (REST/NRSF). REST/NRSF represses transcription of these genes in stem cells and non‐neuronal cells by tethering corepressor compl...

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Publicado en:Protein Sci
Autores principales: Inui, Ken, Zhao, Zongpei, Yuan, Juan, Jayaprakash, Sakthidasan, Le, Le T. M., Drakulic, Srdja, Sander, Bjoern, Golas, Monika M.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405421/
https://ncbi.nlm.nih.gov/pubmed/28218430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3142
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