ISA-2011B, a Phosphatidylinositol 4-Phosphate 5-Kinase α Inhibitor, Impairs CD28-Dependent Costimulatory and Pro-inflammatory Signals in Human T Lymphocytes

Phosphatidylinositol 4,5-biphosphate (PIP2) is a membrane phospholipid that controls the activity of several proteins regulating cytoskeleton reorganization, cytokine gene expression, T cell survival, proliferation, and differentiation. Phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) are the mai...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Kunkl, Martina, Porciello, Nicla, Mastrogiovanni, Marta, Capuano, Cristina, Lucantoni, Federica, Moretti, Chiara, Persson, Jenny L., Galandrini, Ricciarda, Buzzetti, Raffaella, Tuosto, Loretta
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405084/
https://ncbi.nlm.nih.gov/pubmed/28491063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00502
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