Dilation of fusion pores by crowding of SNARE proteins

Hormones and neurotransmitters are released through fluctuating exocytotic fusion pores that can flicker open and shut multiple times. Cargo release and vesicle recycling depend on the fate of the pore, which may reseal or dilate irreversibly. Pore nucleation requires zippering between vesicle-assoc...

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Udgivet i:eLife
Main Authors: Wu, Zhenyong, Bello, Oscar D, Thiyagarajan, Sathish, Auclair, Sarah Marie, Vennekate, Wensi, Krishnakumar, Shyam S, O'Shaughnessy, Ben, Karatekin, Erdem
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Biophysics and Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404929/
https://ncbi.nlm.nih.gov/pubmed/28346138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22964
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