Neurotoxic reactive astrocytes are induced by activated microglia

Reactive astrocytes are strongly induced by central nervous system (CNS) injury and disease but their role is poorly understood. Here we show that A1 reactive astrocytes are induced by classically-activated neuroinflammatory microglia. We show that activated microglia induce A1s by secreting Il-1α,...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Nature
Κύριοι συγγραφείς: Liddelow, Shane A, Guttenplan, Kevin A, Clarke, Laura E, Bennett, Frederick C, Bohlen, Christopher J, Schirmer, Lucas, Bennett, Mariko L, Münch, Alexandra E, Chung, Won-Suk, Peterson, Todd C, Wilton, Daniel K, Frouin, Arnaud, Napier, Brooke A, Panicker, Nikhil, Kumar, Manoj, Buckwalter, Marion S, Rowitch, David H, Dawson, Valina L, Dawson, Ted M, Stevens, Beth, Barres, Ben A
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2017
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404890/
https://ncbi.nlm.nih.gov/pubmed/28099414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21029
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