Neurotoxic reactive astrocytes are induced by activated microglia

Reactive astrocytes are strongly induced by central nervous system (CNS) injury and disease but their role is poorly understood. Here we show that A1 reactive astrocytes are induced by classically-activated neuroinflammatory microglia. We show that activated microglia induce A1s by secreting Il-1α,...

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Publicado en:Nature
Main Authors: Liddelow, Shane A, Guttenplan, Kevin A, Clarke, Laura E, Bennett, Frederick C, Bohlen, Christopher J, Schirmer, Lucas, Bennett, Mariko L, Münch, Alexandra E, Chung, Won-Suk, Peterson, Todd C, Wilton, Daniel K, Frouin, Arnaud, Napier, Brooke A, Panicker, Nikhil, Kumar, Manoj, Buckwalter, Marion S, Rowitch, David H, Dawson, Valina L, Dawson, Ted M, Stevens, Beth, Barres, Ben A
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404890/
https://ncbi.nlm.nih.gov/pubmed/28099414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21029
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