A Ratiometric Sensor for Imaging Insulin Secretion in Single β Cells

Despite the urgent need for assays to visualize insulin secretion there is to date no reliable method available for measuring insulin release from single cells. To address this need, we developed a genetically encoded reporter termed RINS1 based on proinsulin superfolder GFP (sfGFP) and mCherry fusi...

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Bibliographic Details
Published in:Cell Chem Biol
Main Authors: Schifferer, Martina, Yushchenko, Dmytro A., Stein, Frank, Bolbat, Andrey, Schultz, Carsten
Format: Artigo
Language:Inglês
Published: Cell Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404835/
https://ncbi.nlm.nih.gov/pubmed/28366620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.03.001
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