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Engineering Nucleotide Specificity of Succinyl-CoA Synthetase in Blastocystis: The Emerging Role of Gatekeeper Residues
[Image: see text] Charged, solvent-exposed residues at the entrance to the substrate binding site (gatekeeper residues) produce electrostatic dipole interactions with approaching substrates, and control their access by a novel mechanism called “electrostatic gatekeeper effect”. This proof-of-concept...
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| 發表在: | Biochemistry |
|---|---|
| Main Authors: | , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American
Chemical Society
2016
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5404824/ https://ncbi.nlm.nih.gov/pubmed/27478903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00098 |
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