The Bifunctional Enzyme SpoT Is Involved in the Clarithromycin Tolerance of Helicobacter pylori by Upregulating the Transporters HP0939, HP1017, HP0497, and HP0471

Clarithromycin (CLA) is a commonly recommended drug for Helicobacter pylori eradication. However, the prevalence of CLA-resistant H. pylori is increasing. Although point mutations in the 23S rRNA are key factors for CLA resistance, other factors, including efflux pumps and regulation genes, are also...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Geng, Xiwen, Li, Wen, Chen, Zhenghong, Gao, Sizhe, Hong, Wei, Ge, Xiaoran, Hou, Guihua, Hu, Zhekai, Zhou, Yabin, Zeng, Beini, Li, Wenjuan, Jia, Jihui, Sun, Yundong
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404559/
https://ncbi.nlm.nih.gov/pubmed/28242673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02011-16
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