Deletion of nudB Causes Increased Susceptibility to Antifolates in Escherichia coli and Salmonella enterica

Co-trimoxazole, a fixed-dose combination of sulfamethoxazole (SMX) and trimethoprim (TMP), has been used for the treatment of bacterial infections since the 1960s. Since it has long been assumed that the synergistic effects between SMX and TMP are the consequence of targeting 2 different enzymes of...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Li, Kun, Li, Ting, Yang, Shan-shan, Wang, Xu-De, Gao, Lei-xin, Wang, Rui-Qi, Gu, Jing, Zhang, Xian-En, Deng, Jiao-Yu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404538/
https://ncbi.nlm.nih.gov/pubmed/28223385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02378-16
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