Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels.

We have subverted a receptor-mediated endocytosis event to transport genes into human leukemic cells. By coupling the natural iron-delivery protein transferrin to the DNA-binding polycations polylysine or protamine, we have created protein conjugates that bind nucleic acids and carry them into the c...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Cotten, M, Längle-Rouault, F, Kirlappos, H, Wagner, E, Mechtler, K, Zenke, M, Beug, H, Birnstiel, M L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54041/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2349215/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.11.4033
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