Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels.

We have subverted a receptor-mediated endocytosis event to transport genes into human leukemic cells. By coupling the natural iron-delivery protein transferrin to the DNA-binding polycations polylysine or protamine, we have created protein conjugates that bind nucleic acids and carry them into the c...

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Autors principals: Cotten, M, Längle-Rouault, F, Kirlappos, H, Wagner, E, Mechtler, K, Zenke, M, Beug, H, Birnstiel, M L
Format: Artigo
Idioma:Inglês
Publicat: 1990
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC54041/
https://ncbi.nlm.nih.gov/pubmed/2349215
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