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FOXO3 – A Major Gene for Human Longevity

BACKGROUND: The gene FOXO3, encoding the transcription factor forkhead box O-3 (FoxO3), is one of only two for which genetic polymorphisms have exhibited consistent associations with longevity in diverse human populations. OBJECTIVE: Here we review the multitude of actions of FoxO3 that are relevant...

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Publicat a:Gerontology
Autors principals: Morris, Brian J., Willcox, D. Craig, Donlon, Timothy A., Willcox, Bradley J.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5403515/
https://ncbi.nlm.nih.gov/pubmed/25832544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000375235
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