B1, a novel HDAC inhibitor, induces apoptosis through the regulation of STAT3 and NF-κB

We previously demonstrated that B1 induced significant cytotoxic effects, cell cycle G1 arrest and apoptosis in human lung cancer A549 cells through the inhibition of DNA topoisomerase II activity. In the present study, we focused on the histone deacetylase (HDAC) modulation of B1 in A549 cells. HDA...

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Vydáno v:Int J Mol Med
Hlavní autoři: Cheng, Meng-Hsuan, Wong, Yun-Hong, Chang, Chia-Ming, Yang, Chun-Chien, Chen, Shih-Hua, Yuan, Chun-Lung, Kuo, Hsiao-Mei, Yang, Chun-Yuh, Chiu, Hui-Fen
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5403210/
https://ncbi.nlm.nih.gov/pubmed/28393178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2017.2946
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