Nucleolar aggresomes mediate release of pericentric heterochromatin and nuclear destruction of genotoxically treated cancer cells

The role of the nucleolus and autophagy in maintenance of nuclear integrity is poorly understood. In addition, the mechanisms of nuclear destruction in cancer cells senesced after conventional chemotherapy are unclear. In an attempt to elucidate these issues, we studied teratocarcinoma PA1 cells tre...

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Publicado en:Nucleus
Autores principales: Salmina, Kristine, Huna, Anda, Inashkina, Inna, Belyayev, Alexander, Krigerts, Jekabs, Pastova, Ladislava, Vazquez-Martin, Alejandro, Erenpreisa, Jekaterina
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2017
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5403147/
https://ncbi.nlm.nih.gov/pubmed/28068183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2017.1279775
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