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Nucleolar aggresomes mediate release of pericentric heterochromatin and nuclear destruction of genotoxically treated cancer cells

The role of the nucleolus and autophagy in maintenance of nuclear integrity is poorly understood. In addition, the mechanisms of nuclear destruction in cancer cells senesced after conventional chemotherapy are unclear. In an attempt to elucidate these issues, we studied teratocarcinoma PA1 cells tre...

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Dades bibliogràfiques
Publicat a:Nucleus
Autors principals: Salmina, Kristine, Huna, Anda, Inashkina, Inna, Belyayev, Alexander, Krigerts, Jekabs, Pastova, Ladislava, Vazquez-Martin, Alejandro, Erenpreisa, Jekaterina
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5403147/
https://ncbi.nlm.nih.gov/pubmed/28068183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2017.1279775
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