Nucleolar aggresomes mediate release of pericentric heterochromatin and nuclear destruction of genotoxically treated cancer cells

The role of the nucleolus and autophagy in maintenance of nuclear integrity is poorly understood. In addition, the mechanisms of nuclear destruction in cancer cells senesced after conventional chemotherapy are unclear. In an attempt to elucidate these issues, we studied teratocarcinoma PA1 cells tre...

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Dettagli Bibliografici
Pubblicato in:Nucleus
Autori principali: Salmina, Kristine, Huna, Anda, Inashkina, Inna, Belyayev, Alexander, Krigerts, Jekabs, Pastova, Ladislava, Vazquez-Martin, Alejandro, Erenpreisa, Jekaterina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2017
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5403147/
https://ncbi.nlm.nih.gov/pubmed/28068183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2017.1279775
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