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Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes

Cells have evolved intricate mechanisms to maintain genome stability despite allowing mutational changes to drive evolutionary adaptation. Repetitive DNA sequences, which represent the bulk of most genomes, are a major threat to genome stability often driving chromosome rearrangements and disease. T...

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Détails bibliographiques
Publié dans:Nucleus
Auteurs principaux: Hall, Amanda C., Ostrowski, Lauren A., Pietrobon, Violena, Mekhail, Karim
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5403138/
https://ncbi.nlm.nih.gov/pubmed/28406751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2017.1292193
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