The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans

BACKGROUND: Human carboxylesterase 1 (CES1) is a serine esterase that hydrolyses various exogenous and endogenous compounds including oseltamivir, a prodrug used to treat influenza. A novel CES1 c.662A>G single nucleotide polymorphism (SNP) was predicted to decrease CES1 enzymatic activity in an...

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Publicat a:PLoS One
Autors principals: Oh, Jaeseong, Lee, SeungHwan, Lee, Howard, Cho, Joo-Youn, Yoon, Seo Hyun, Jang, In-Jin, Yu, Kyung-Sang, Lim, Kyoung Soo
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402961/
https://ncbi.nlm.nih.gov/pubmed/28437488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176320
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