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Role of cleavage at the core-E1 junction of hepatitis C virus polyprotein in viral morphogenesis

In hepatitis C virus (HCV) polyprotein sequence, core protein terminates with E1 envelope signal peptide. Cleavage by signal peptidase (SP) separates E1 from the complete form of core protein, anchored in the endoplasmic reticulum (ER) membrane by the signal peptide. Subsequent cleavage of the signa...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Pène, Véronique, Lemasson, Matthieu, Harper, Francis, Pierron, Gérard, Rosenberg, Arielle R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402940/
https://ncbi.nlm.nih.gov/pubmed/28437468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0175810
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