Clustered Protocadherins Are Required for Building Functional Neural Circuits

Neuronal identity is generated by the cell-surface expression of clustered protocadherin (Pcdh) isoforms. In mice, 58 isoforms from three gene clusters, Pcdhα, Pcdhβ, and Pcdhγ, are differentially expressed in neurons. Since cis-heteromeric Pcdh oligomers on the cell surface interact homophilically...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Hasegawa, Sonoko, Kobayashi, Hiroaki, Kumagai, Makiko, Nishimaru, Hiroshi, Tarusawa, Etsuko, Kanda, Hiro, Sanbo, Makoto, Yoshimura, Yumiko, Hirabayashi, Masumi, Hirabayashi, Takahiro, Yagi, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5401904/
https://ncbi.nlm.nih.gov/pubmed/28484370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00114
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