Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting

The clustered protocadherin (Pcdh) genes are divided into the Pcdhα, Pcdhβ, and Pcdhγ clusters. Gene-disruption analyses in mice have revealed the in vivo functions of the Pcdhα and Pcdhγ clusters. However, all Pcdh protein isoforms form combinatorial cis-hetero dimers and enter trans-homophilic int...

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Dettagli Bibliografici
Pubblicato in:Front Mol Neurosci
Autori principali: Hasegawa, Sonoko, Kumagai, Makiko, Hagihara, Mitsue, Nishimaru, Hiroshi, Hirano, Keizo, Kaneko, Ryosuke, Okayama, Atsushi, Hirayama, Teruyoshi, Sanbo, Makoto, Hirabayashi, Masumi, Watanabe, Masahiko, Hirabayashi, Takahiro, Yagi, Takeshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2016
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5179546/
https://ncbi.nlm.nih.gov/pubmed/28066179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2016.00155
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