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Spatiotemporal Mapping Techniques Show Clozapine Impairs Neurogenic and Myogenic Patterns of Activity in the Colon of the Rabbit in a Dose-Dependent Manner

Background: Clozapine, an antipsychotic used in treatment-resistant schizophrenia, has adverse gastrointestinal effects with significant associated morbidity and mortality. However, its effects on defined patterns of colonic contractile activity have not been assessed. Method: We used novel radial a...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Every-Palmer, Susanna, Lentle, Roger G., Reynolds, Gordon, Hulls, Corrin, Chambers, Paul, Dunn, Helen, Ellis, Pete M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5401895/
https://ncbi.nlm.nih.gov/pubmed/28484390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00209
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