Nuclear-specific AR-V7 Protein Localization is Necessary to Guide Treatment Selection in Metastatic Castration-resistant Prostate Cancer

BACKGROUND: Circulating tumor cells (CTCs) expressing AR-V7 protein localized to the nucleus (nuclear-specific) identify metastatic castration-resistant prostate cancer (mCRPC) patients with improved overall survival (OS) on taxane therapy relative to the androgen receptor signaling inhibitors (ARSi...

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Publicado en:Eur Urol
Main Authors: Scher, Howard I., Graf, Ryon P., Schreiber, Nicole A., McLaughlin, Brigit, Lu, David, Louw, Jessica, Danila, Daniel C., Dugan, Lyndsey, Johnson, Ann, Heller, Glenn, Fleisher, Martin, Dittamore, Ryan
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5401782/
https://ncbi.nlm.nih.gov/pubmed/27979426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2016.11.024
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