Quality of TCR signaling encoded by differential enhancer affinities for the composite BATF-IRF4 transcription factor complex

Variable strengths of T cell receptor (TCR) signaling can produce divergent outcomes, but the mechanism remains obscure. The abundance of the transcription factor IRF4 increases with TCR signal strength, but how this would induce distinct types of responses is unclear. We compared T(H)2 gene express...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Iwata, Arifumi, Durai, Vivek, Tussiwand, Roxane, Briseño, Carlos G., Wu, Xiaodi, Grajales-Reyes, Gary E., Egawa, Takeshi, Murphy, Theresa L., Murphy, Kenneth M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5401770/
https://ncbi.nlm.nih.gov/pubmed/28346410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3714
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