Cryptococcus neoformans Isolates from Transplant Recipients Are Not Selected for Resistance to Calcineurin Inhibitors by Current Immunosuppressive Regimens

The immunosuppressants tacrolimus (FK506) and cyclosporine A inhibit calcineurin and have potent antifungal activity. In this study, 24% of Cryptococcus neoformans isolates from solid-organ transplant patients exhibited altered sensitivity to these drugs, which may have an impact on the infectious c...

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Bibliografiske detaljer
Main Authors: Blankenship, Jill R., Singh, Nina, Alexander, Barbara D., Heitman, Joseph
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Mycology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC540157/
https://ncbi.nlm.nih.gov/pubmed/15635017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.43.1.464-467.2005
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