Cryptococcus neoformans Isolates from Transplant Recipients Are Not Selected for Resistance to Calcineurin Inhibitors by Current Immunosuppressive Regimens

The immunosuppressants tacrolimus (FK506) and cyclosporine A inhibit calcineurin and have potent antifungal activity. In this study, 24% of Cryptococcus neoformans isolates from solid-organ transplant patients exhibited altered sensitivity to these drugs, which may have an impact on the infectious c...

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Bibliographic Details
Published in:J Clin Microbiol
Main Authors: Blankenship, Jill R., Singh, Nina, Alexander, Barbara D., Heitman, Joseph
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2005
Subjects:
Mycology
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC540157/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15635017/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JCM.43.1.464-467.2005
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