Pevonedistat, a Nedd8-activating enzyme inhibitor, sensitizes neoplastic B-cells to death receptor-mediated apoptosis

While death receptor ligands (Fas and TRAIL) kill chemoresistant tumor cell lines, related therapies have limited clinical efficacy as single agents. Death receptor signaling is modulated by nuclear factor-κB (NFκB), a family of transcription factors which are constitutively active in B-cell maligna...

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發表在:Oncotarget
Main Authors: Paiva, Cody, Claire Godbersen, J., Rowland, Taylor, Danilova, Olga V., Danes, Christopher, Berger, Allison, Danilov, Alexey V.
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2017
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400571/
https://ncbi.nlm.nih.gov/pubmed/28177892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15050
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