Pevonedistat, a Nedd8-activating enzyme inhibitor, sensitizes neoplastic B-cells to death receptor-mediated apoptosis

While death receptor ligands (Fas and TRAIL) kill chemoresistant tumor cell lines, related therapies have limited clinical efficacy as single agents. Death receptor signaling is modulated by nuclear factor-κB (NFκB), a family of transcription factors which are constitutively active in B-cell maligna...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Paiva, Cody, Claire Godbersen, J., Rowland, Taylor, Danilova, Olga V., Danes, Christopher, Berger, Allison, Danilov, Alexey V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2017
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400571/
https://ncbi.nlm.nih.gov/pubmed/28177892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15050
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