Pevonedistat, a Nedd8-activating enzyme inhibitor, sensitizes neoplastic B-cells to death receptor-mediated apoptosis

While death receptor ligands (Fas and TRAIL) kill chemoresistant tumor cell lines, related therapies have limited clinical efficacy as single agents. Death receptor signaling is modulated by nuclear factor-κB (NFκB), a family of transcription factors which are constitutively active in B-cell maligna...

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Detalles Bibliográficos
Publicado en:Oncotarget
Autores principales: Paiva, Cody, Claire Godbersen, J., Rowland, Taylor, Danilova, Olga V., Danes, Christopher, Berger, Allison, Danilov, Alexey V.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400571/
https://ncbi.nlm.nih.gov/pubmed/28177892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15050
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