Ezrin activation by LOK phosphorylation involves a PIP(2)-dependent wedge mechanism

How cells specify morphologically distinct plasma membrane domains is poorly understood. Prior work has shown that restriction of microvilli to the apical aspect of epithelial cells requires the localized activation of the membrane-F-actin linking protein ezrin. Using an in vitro system, we now defi...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Pelaseyed, Thaher, Viswanatha, Raghuvir, Sauvanet, Cécile, Filter, Joshua J, Goldberg, Michael L, Bretscher, Anthony
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2017
Teme:
Biochemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400502/
https://ncbi.nlm.nih.gov/pubmed/28430576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22759
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