Ezrin activation by LOK phosphorylation involves a PIP(2)-dependent wedge mechanism

How cells specify morphologically distinct plasma membrane domains is poorly understood. Prior work has shown that restriction of microvilli to the apical aspect of epithelial cells requires the localized activation of the membrane-F-actin linking protein ezrin. Using an in vitro system, we now defi...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Pelaseyed, Thaher, Viswanatha, Raghuvir, Sauvanet, Cécile, Filter, Joshua J, Goldberg, Michael L, Bretscher, Anthony
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2017
Onderwerpen:
Biochemistry
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400502/
https://ncbi.nlm.nih.gov/pubmed/28430576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22759
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