Application of Suzuki-Miyaura and Buchwald-Hartwig Cross-coupling Reactions to the Preparation of Substituted 1,2,4-Benzotriazine 1-Oxides Related to the Antitumor Agent Tirapazamine

[Image: see text] Many 1,2,4-benzotriazine 1,4-dioxides display the ability to selectively kill the oxygen-poor cells found in solid tumors. As a result, there is a desire for synthetic routes that afford access to substituted 1,2,4-benzotriazine 1-oxides that can be used as direct precursors in the...

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Veröffentlicht in:J Heterocycl Chem
Hauptverfasser: Sarkar, Ujjal, Hillebrand, Roman, Johnson, Kevin M., Cummings, Andrea H., Phung, Ngoc Linh, Rajapakse, Anuruddha, Zhou, Haiying, Willis, Jordan R., Barnes, Charles, L., Gates, Kent S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400285/
https://ncbi.nlm.nih.gov/pubmed/28439141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jhet.2559
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