NaCl cotransporter abundance in urinary vesicles is increased by calcineurin inhibitors and predicts thiazide sensitivity

Animal studies have shown that the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus can activate the thiazide-sensitive NaCl cotransporter (NCC). A common side effect of CNIs is hypertension. Renal salt transporters such as NCC are excreted in urinary extracellular vesicles (uEVs) after int...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Tutakhel, Omar A. Z., Moes, Arthur D., Valdez-Flores, Marco A., Kortenoeven, Marleen L. A., Vrie, Mathijs v. D., Jeleń, Sabina, Fenton, Robert A., Zietse, Robert, Hoenderop, Joost G. J., Hoorn, Ewout J., Hilbrands, Luuk, Bindels, René J. M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400280/
https://ncbi.nlm.nih.gov/pubmed/28430812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176220
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