NaCl cotransporter abundance in urinary vesicles is increased by calcineurin inhibitors and predicts thiazide sensitivity

Animal studies have shown that the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus can activate the thiazide-sensitive NaCl cotransporter (NCC). A common side effect of CNIs is hypertension. Renal salt transporters such as NCC are excreted in urinary extracellular vesicles (uEVs) after int...

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Pubblicato in:PLoS One
Autori principali: Tutakhel, Omar A. Z., Moes, Arthur D., Valdez-Flores, Marco A., Kortenoeven, Marleen L. A., Vrie, Mathijs v. D., Jeleń, Sabina, Fenton, Robert A., Zietse, Robert, Hoenderop, Joost G. J., Hoorn, Ewout J., Hilbrands, Luuk, Bindels, René J. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400280/
https://ncbi.nlm.nih.gov/pubmed/28430812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176220
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