Reprogramming towards totipotency is greatly facilitated by synergistic effects of small molecules

Animal cloning has been achieved in many species by transplanting differentiated cell nuclei to unfertilized oocytes. However, the low efficiencies of cloning have remained an unresolved issue. Here we find that the combination of two small molecules, trichostatin A (TSA) and vitamin C (VC), under c...

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Veröffentlicht in:Biol Open
Hauptverfasser: Miyamoto, Kei, Tajima, Yosuke, Yoshida, Koki, Oikawa, Mami, Azuma, Rika, Allen, George E., Tsujikawa, Tomomi, Tsukaguchi, Tomomasa, Bradshaw, Charles R., Jullien, Jerome, Yamagata, Kazuo, Matsumoto, Kazuya, Anzai, Masayuki, Imai, Hiroshi, Gurdon, John B., Yamada, Masayasu
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399555/
https://ncbi.nlm.nih.gov/pubmed/28412714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.023473
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