Gene Resistance to Transcriptional Reprogramming following Nuclear Transfer Is Directly Mediated by Multiple Chromatin-Repressive Pathways

Understanding the mechanism of resistance of genes to reactivation will help improve the success of nuclear reprogramming. Using mouse embryonic fibroblast nuclei with normal or reduced DNA methylation in combination with chromatin modifiers able to erase H3K9me3, H3K27me3, and H2AK119ub1 from trans...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Jullien, Jerome, Vodnala, Munender, Pasque, Vincent, Oikawa, Mami, Miyamoto, Kei, Allen, George, David, Sarah Anne, Brochard, Vincent, Wang, Stan, Bradshaw, Charles, Koseki, Haruhiko, Sartorelli, Vittorio, Beaujean, Nathalie, Gurdon, John
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344684/
https://ncbi.nlm.nih.gov/pubmed/28257702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.01.030
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