Neutrophil stunning by metoprolol reduces infarct size

The β1-adrenergic-receptor (ADRB1) antagonist metoprolol reduces infarct size in acute myocardial infarction (AMI) patients. The prevailing view has been that metoprolol acts mainly on cardiomyocytes. Here, we demonstrate that metoprolol reduces reperfusion injury by targeting the haematopoietic com...

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發表在:Nat Commun
Main Authors: García-Prieto, Jaime, Villena-Gutiérrez, Rocío, Gómez, Mónica, Bernardo, Esther, Pun-García, Andrés, García-Lunar, Inés, Crainiciuc, Georgiana, Fernández-Jiménez, Rodrigo, Sreeramkumar, Vinatha, Bourio-Martínez, Rafael, García-Ruiz, José M, del Valle, Alfonso Serrano, Sanz-Rosa, David, Pizarro, Gonzalo, Fernández-Ortiz, Antonio, Hidalgo, Andrés, Fuster, Valentín, Ibanez, Borja
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399300/
https://ncbi.nlm.nih.gov/pubmed/28416795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14780
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