Variable region in streptococcal M-proteins provides stable binding with host fibrinogen for plasminogen-mediated bacterial invasion

Dimeric M-proteins (M-Prt) in group A Streptococcus pyogenes (GAS) are surface-expressed virulence factors implicated in processes that contribute to the pathogenicity of infection. Sequence analyses of various GAS M-Prts have shown that they contain a highly conserved sortase A-dependent cell wall-...

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Vydáno v:J Biol Chem
Hlavní autoři: Glinton, Kristofor, Beck, Julia, Liang, Zhong, Qiu, Cunjia, Lee, Shaun W., Ploplis, Victoria A., Castellino, Francis J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399124/
https://ncbi.nlm.nih.gov/pubmed/28280245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.768937
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