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The p53-binding protein 1-Tudor-interacting repair regulator complex participates in the DNA damage response
The 53BP1-dependent end-joining pathway plays a critical role in double strand break repair and is uniquely responsible for cellular sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPi) in BRCA1-deficient cancers. We and others have investigated the downstream effectors of 53BP1, including...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5399100/ https://ncbi.nlm.nih.gov/pubmed/28213517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.777474 |
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