Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment

There is increasing interest in the use of quantitative transcriptomic data to determine benchmark dose (BMD) and estimate a point of departure (POD) for human health risk assessment. Although studies have shown that transcriptional PODs correlate with those derived from apical endpoint changes, the...

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Dades bibliogràfiques
Publicat a:Arch Toxicol
Autors principals: Farmahin, Reza, Williams, Andrew, Kuo, Byron, Chepelev, Nikolai L., Thomas, Russell S., Barton-Maclaren, Tara S., Curran, Ivan H., Nong, Andy, Wade, Michael G., Yauk, Carole L.
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2016
Matèries:
Regulatory Toxicology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399047/
https://ncbi.nlm.nih.gov/pubmed/27928627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1886-5
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