Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment

There is increasing interest in the use of quantitative transcriptomic data to determine benchmark dose (BMD) and estimate a point of departure (POD) for human health risk assessment. Although studies have shown that transcriptional PODs correlate with those derived from apical endpoint changes, the...

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Опубликовано в: :Arch Toxicol
Главные авторы: Farmahin, Reza, Williams, Andrew, Kuo, Byron, Chepelev, Nikolai L., Thomas, Russell S., Barton-Maclaren, Tara S., Curran, Ivan H., Nong, Andy, Wade, Michael G., Yauk, Carole L.
Формат: Artigo
Язык:Inglês
Опубликовано: Springer Berlin Heidelberg 2016
Предметы:
Regulatory Toxicology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399047/
https://ncbi.nlm.nih.gov/pubmed/27928627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1886-5
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