Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment

There is increasing interest in the use of quantitative transcriptomic data to determine benchmark dose (BMD) and estimate a point of departure (POD) for human health risk assessment. Although studies have shown that transcriptional PODs correlate with those derived from apical endpoint changes, the...

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Detaylı Bibliyografya
Yayımlandı:Arch Toxicol
Asıl Yazarlar: Farmahin, Reza, Williams, Andrew, Kuo, Byron, Chepelev, Nikolai L., Thomas, Russell S., Barton-Maclaren, Tara S., Curran, Ivan H., Nong, Andy, Wade, Michael G., Yauk, Carole L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer Berlin Heidelberg 2016
Konular:
Regulatory Toxicology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399047/
https://ncbi.nlm.nih.gov/pubmed/27928627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1886-5
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