HIV-1 and SIV Predominantly Use CCR5 Expressed on a Precursor Population to Establish Infection in T Follicular Helper Cells

BACKGROUND: T follicular helper (Tfh) cells are increasingly recognized as a major reservoir of HIV infection that will likely need to be addressed in approaches to curing HIV. However, Tfh express minimal CCR5, the major coreceptor for HIV-1, and the mechanism by which they are infected is unclear....

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Xu, Yin, Phetsouphanh, Chansavath, Suzuki, Kazuo, Aggrawal, Anu, Graff-Dubois, Stephanie, Roche, Michael, Bailey, Michelle, Alcantara, Sheilajen, Cashin, Kieran, Sivasubramaniam, Rahuram, Koelsch, Kersten K., Autran, Brigitte, Harvey, Richard, Gorry, Paul R., Moris, Arnaud, Cooper, David A., Turville, Stuart, Kent, Stephen J., Kelleher, Anthony D., Zaunders, John
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399036/
https://ncbi.nlm.nih.gov/pubmed/28484447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00376
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