Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer

Approximately 75% of breast cancers express estrogen receptor α (ERα) and depend on estrogen signals for continued growth. Aromatase inhibitors (AIs) prevent estrogen production and inhibit estrogen receptor signaling, resulting in decreased cancer recurrence and mortality. Advanced tumors treated w...

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Publicado no:Oncogene
Main Authors: Hiken, Jeffrey F., McDonald, James I., Decker, Keith F., Sanchez, Cesar, Hoog, Jeremy, VanderKraats, Nathan D., Jung, Kyle L., Akinhanmi, Margaret, Rois, Lisa E., Ellis, Matthew J., Edwards, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5398938/
https://ncbi.nlm.nih.gov/pubmed/27869171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.397
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