MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas

Metaplastic breast carcinoma is an aggressive form of invasive breast cancer with histological evidence of epithelial to mesenchymal transition (EMT). However, the defining molecular events are unknown. Here we show that CCN6 (WISP3), a secreted matricellular protein of the CCN (CYR61/CTGF/NOV) fami...

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Pubblicato in:Oncogene
Autori principali: Martin, Emily E., Huang, Wei, Anwar, Talha, Arellano-Garcia, Caroline, Burman, Boris, Guan, Jun-Lin, Gonzalez, Maria E., Kleer, Celina G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5398917/
https://ncbi.nlm.nih.gov/pubmed/27819674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.381
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