Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7

PURPOSE: To examine the effects of autophagy deficiency induced by RPE-specific deletion of Atg5 or Atg7 in mice as a function of age. METHODS: Conditional knockout mice with a floxed allele of Atg5 or Atg7 were crossed with inducible VMD2-rtTA/Cre transgenic mice. VMD2-directed RPE-specific Cre rec...

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Vydáno v:Mol Vis
Hlavní autoři: Zhang, Youwen, Cross, Samuel D., Stanton, James B., Marmorstein, Alan D., Le, Yun Zheng, Marmorstein, Lihua Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: Molecular Vision 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5398883/
https://ncbi.nlm.nih.gov/pubmed/28465655
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