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Targeted DNA demethylation in human cells by fusion of a plant 5-methylcytosine DNA glycosylase to a sequence-specific DNA binding domain

DNA methylation is a crucial epigenetic mark associated to gene silencing, and its targeted removal is a major goal of epigenetic editing. In animal cells, DNA demethylation involves iterative 5mC oxidation by TET enzymes followed by replication-dependent dilution and/or replication-independent DNA...

詳細記述

保存先:
書誌詳細
出版年:Epigenetics
主要な著者: Parrilla-Doblas, Jara Teresa, Ariza, Rafael R., Roldán-Arjona, Teresa
フォーマット: Artigo
言語:Inglês
出版事項: Taylor & Francis 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5398769/
https://ncbi.nlm.nih.gov/pubmed/28277978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2017.1294306
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