Regulation of SESAME-mediated H3T11 phosphorylation by glycolytic enzymes and metabolites

Cancer cells prefer aerobic glycolysis, but little is known about the underlying mechanism. Recent studies showed that the rate-limiting glycolytic enzymes, pyruvate kinase M2 (PKM2) directly phosphorylates H3 at threonine 11 (H3T11) to regulate gene expression and cell proliferation, revealing its...

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Publicat a:PLoS One
Autors principals: Yu, Qi, Tong, Chong, Luo, Mingdan, Xue, Xiangyan, Mei, Qianyun, Ma, Lixin, Yu, Xiaolan, Mao, Wuxiang, Kong, Lingbao, Yu, Xilan, Li, Shanshan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5398556/
https://ncbi.nlm.nih.gov/pubmed/28426732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0175576
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