Immune toxicities elicted by CTLA-4 blockade in cancer patients are associated with early diversification of the T cell repertoire

While immune checkpoint blockade elicits efficacious responses in many cancer patients, it also produces a diverse and unpredictable number of immune-related adverse events (IRAE). Mechanisms driving IRAE are generally unknown. Because CTLA-4 blockade leads to proliferation of circulating T cells, w...

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Foilsithe in:Cancer Res
Main Authors: Oh, David Y., Cham, Jason, Zhang, Li, Fong, Grant, Kwek, Serena S., Klinger, Mark, Faham, Malek, Fong, Lawrence
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5398199/
https://ncbi.nlm.nih.gov/pubmed/28031229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2324
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